Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency

Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise, particularly for cross-reactive an...

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Main Authors: Tharakaraman, Kannan, Robinson, Luke N., Hatas, Andrew, Chen, Yi-Ling, Siyue, Liu, Raguram, S., Sasisekharan, V., Wogan, Gerald N., Sasisekharan, Ram
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637786/
https://ncbi.nlm.nih.gov/pubmed/23569282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303645110
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