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Redesign of a cross-reactive antibody to dengue virus with broad-spectrum activity and increased in vivo potency
Affinity improvement of proteins, including antibodies, by computational chemistry broadly relies on physics-based energy functions coupled with refinement. However, achieving significant enhancement of binding affinity (>10-fold) remains a challenging exercise, particularly for cross-reactive an...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637786/ https://ncbi.nlm.nih.gov/pubmed/23569282 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303645110 |
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