Receptor-mediated endocytosis and endosomal acidification is impaired in proximal tubule epithelial cells of Dent disease patients

Receptor-mediated endocytosis, involving megalin and cubilin, mediates renal proximal-tubular reabsorption and is decreased in Dent disease because of mutations of the chloride/proton antiporter, chloride channel-5 (CLC-5), resulting in low-molecular-weight proteinuria, hypercalciuria, nephrolithias...

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Autori principali: Gorvin, Caroline M., Wilmer, Martijn J., Piret, Sian E., Harding, Brian, van den Heuvel, Lambertus P., Wrong, Oliver, Jat, Parmjit S., Lippiat, Jonathan D., Levtchenko, Elena N., Thakker, Rajesh V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2013
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637698/
https://ncbi.nlm.nih.gov/pubmed/23572577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302063110
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