Rates of mutation to growth factor autonomy and tumorigenicity differ in hematopoietic stem and precursor cells expressing the multilineage colony-stimulating factor gene.

At least two separate but interdependent events are required to attain autonomous growth as a consequence of ectopic expression of the multilineage colony-stimulating factor gene in hematopoietic progenitor cells. The rate at which the second event occurs is more than 3 orders of magnitude higher in...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Laker, C, Kluge, N, Stocking, C, Just, U, Franz, M J, Ostertag, W, DeLamarter, J F, Dexter, M, Spooncer, E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2586530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.12.5746-5749.1989
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