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Sickle cell vaso-occlusion causes activation of iNKT cells that is decreased by the adenosine A(2A) receptor agonist regadenoson
Adenosine A(2A) receptor (A(2A)R) agonists reduce invariant natural killer T (iNKT) cell activation and decrease inflammation in sickle cell disease (SCD) mice. We conducted a phase 1 trial of the A(2A)R agonist regadenoson in adults with SCD. The target dose was 1.44 μg/kg/h. iNKT cell activation w...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637009/ https://ncbi.nlm.nih.gov/pubmed/23377438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-465963 |
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