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Synthesis of N(2)-modified 7-methylguanosine 5’-monophosphates as nematode translation inhibitors

Preparative scale synthesis of fourteen new N(2)-modified mononucleotide 5’ mRNA cap analogues was achieved. The key step involved use of an S(N)Ar reaction with protected 2-fluoro inosine and various primary and secondary amines. The derivatives were tested in a parasitic nematode, Ascaris suum, ce...

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Bibliografische gegevens
Hoofdauteurs: Piecyk, Karolina, Davis, Richard E., Jankowska-Anyszka, Marzena
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636719/
https://ncbi.nlm.nih.gov/pubmed/22748379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.078
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