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Synthesis of N(2)-modified 7-methylguanosine 5’-monophosphates as nematode translation inhibitors
Preparative scale synthesis of fourteen new N(2)-modified mononucleotide 5’ mRNA cap analogues was achieved. The key step involved use of an S(N)Ar reaction with protected 2-fluoro inosine and various primary and secondary amines. The derivatives were tested in a parasitic nematode, Ascaris suum, ce...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636719/ https://ncbi.nlm.nih.gov/pubmed/22748379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.078 |
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