ASIC3 deficiency increases inflammation but decreases pain behavior in arthritis

OBJECTIVE: Through its location on nociceptors, acid sensing ion channel 3 (ASIC3) is activated by decreases in pH and plays a significant role in musculoskeletal pain. We recently showed that decreases in pH activate ASIC3 located on fibroblast-like synoviocytes (FLS). Since FLS are key cells in th...

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Detalhes bibliográficos
Main Authors: Sluka, Kathleen A., Rasmussen, Lynn A., Edgar, Meghan M., O’Donnell, James M., Walder, RoxanneY., Kolker, Sandra J., Boyle, David L, Firestein, Gary S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636153/
https://ncbi.nlm.nih.gov/pubmed/23335302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37862
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