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Selective targeting of ASIC3 using artificial miRNAs inhibits primary and secondary hyperalgesia after muscle inflammation

Acid-sensing ion channels (ASICs) are activated by acidic pH and may play a significant role in the development of hyperalgesia. Earlier studies show ASIC3 is important for induction of hyperalgesia after muscle insult using ASIC3−/− mice. ASIC3−/− mice lack ASIC3 throughout the body, and the distri...

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Detalhes bibliográficos
Main Authors: Walder, Roxanne Y., Gautam, Mamta, Wilson, Steven P., Benson, Christopher J., Sluka, Kathleen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3476729/
https://ncbi.nlm.nih.gov/pubmed/21843914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2011.06.027
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