Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the “missing heritability” of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disease risk ar...

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Main Authors: Andreassen, Ole A., Thompson, Wesley K., Schork, Andrew J., Ripke, Stephan, Mattingsdal, Morten, Kelsoe, John R., Kendler, Kenneth S., O'Donovan, Michael C., Rujescu, Dan, Werge, Thomas, Sklar, Pamela, Roddey, J. Cooper, Chen, Chi-Hua, McEvoy, Linda, Desikan, Rahul S., Djurovic, Srdjan, Dale, Anders M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636100/
https://ncbi.nlm.nih.gov/pubmed/23637625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003455
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