Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

Several lines of evidence suggest that genome-wide association studies (GWAS) have the potential to explain more of the “missing heritability” of common complex phenotypes. However, reliable methods to identify a larger proportion of single nucleotide polymorphisms (SNPs) that impact disease risk ar...

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Autori principali: Andreassen, Ole A., Thompson, Wesley K., Schork, Andrew J., Ripke, Stephan, Mattingsdal, Morten, Kelsoe, John R., Kendler, Kenneth S., O'Donovan, Michael C., Rujescu, Dan, Werge, Thomas, Sklar, Pamela, Roddey, J. Cooper, Chen, Chi-Hua, McEvoy, Linda, Desikan, Rahul S., Djurovic, Srdjan, Dale, Anders M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636100/
https://ncbi.nlm.nih.gov/pubmed/23637625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003455
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