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Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway.

We have selected mutations in genes encoding components of the signaling pathway for alpha interferon (IFN-alpha) by using a specially constructed cell line. The upstream region of the IFN-regulated human gene 6-16 was fused to the Escherichia coli guanine phosphoribosyltransferase (gpt) gene and tr...

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Publicado en:Mol Cell Biol
Autores principales: Pellegrini, S, John, J, Shearer, M, Kerr, I M, Stark, G R
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 1989
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Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363606/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2513475/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.11.4605
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