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Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application

Curdlan sulfate (CRDS), a sulfated 1→3-β-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). CRDS was identified by in silico blind docking studies to exhibit binding potential to the envelope (E) protein of...

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Bibliografiske detaljer
Main Authors: Ichiyama, Koji, Gopala Reddy, Sindhoora Bhargavi, Zhang, Li Feng, Chin, Wei Xin, Muschin, Tegshi, Heinig, Lars, Suzuki, Youichi, Nanjundappa, Haraprasad, Yoshinaka, Yoshiyuki, Ryo, Akihide, Nomura, Nobuo, Ooi, Eng Eong, Vasudevan, Subhash G., Yoshida, Takashi, Yamamoto, Naoki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636050/
https://ncbi.nlm.nih.gov/pubmed/23658845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002188
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