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Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application
Curdlan sulfate (CRDS), a sulfated 1→3-β-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). CRDS was identified by in silico blind docking studies to exhibit binding potential to the envelope (E) protein of...
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Main Authors: | , , , , , , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Public Library of Science
2013
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636050/ https://ncbi.nlm.nih.gov/pubmed/23658845 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0002188 |
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