Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

IFN-γ activates cells to restrict intracellular pathogens by upregulating cellular effectors including the p65 family of guanylate-binding proteins (GBPs). Here we test the role of Gbp1 in the IFN-γ-dependent control of T. gondii in the mouse model. Virulent strains of T. gondii avoided recruitment...

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Detalhes bibliográficos
Main Authors: Selleck, Elizabeth M., Fentress, Sarah J., Beatty, Wandy L., Degrandi, Daniel, Pfeffer, Klaus, Virgin, Herbert W., MacMicking, John D., Sibley, L. David
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635975/
https://ncbi.nlm.nih.gov/pubmed/23633952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003320
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