Pharmacokinetics and central nervous system effects of the novel dual NK(1)/NK(3) receptor antagonist GSK1144814 in alcohol-intoxicated volunteers

AIMS: Antagonism of both NK(1) and NK(3) receptors may be an effective strategy in the pharmacotherapy of schizophrenia, drug addiction or depression. GSK1144814 is a novel selective dual NK(1)/NK(3) receptor antagonist. The potential influence of GSK1144814 on the effects of alcohol was investigate...

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Dettagli Bibliografici
Autori principali: te Beek, Erik T, Hay, Justin L, Bullman, Jonathan N, Burgess, Clare, Nahon, Kimberly J, Klaassen, Erica S, Gray, Frank A, Gerven, Joop M A
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2013
Soggetti:
Drug Interactions
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3635603/
https://ncbi.nlm.nih.gov/pubmed/23067311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12004
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