A dominant trifluoperazine resistance gene from Saccharomyces cerevisiae has homology with F0F1 ATP synthase and confers calcium-sensitive growth.

The antipsychotic drug trifluoperazine has been long considered a calmodulin inhibitor from in vitro studies but may function in vivo as a more general inhibitor by disturbing ion fluxes and altering the membrane potential. Resistance to trifluoperazine can arise in Saccharomyces cerevisiae cells by...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Shih, C K, Wagner, R, Feinstein, S, Kanik-Ennulat, C, Neff, N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2905423/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.8.3094-3103.1988
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