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Integrating de novo Sequencing and Database Search for Monoclonal Antibody Sequencing
A mass spectrometry-based workflow for sequencing the monoclonal antibodies was presented. It combined multi-enzyme digestion, acquisition of high-resolution on both precursor and fragment steps, and integration of database search and de novo sequencing. All MS/MS spectra were first searched against...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Association of Biomolecular Resource Facilities
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635332/ |
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