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BCNU-sequestration by metallothioneins may contribute to a medulloblastoma cell line’s BCNU-resistance
Metallothioneins (MTs), due to the prevalence of reactive thiol groups have previously been shown to quench various DNA alkylating compounds. Here, we present initial results which demonstrate that MTs can also sequester BCNU in simulated physiological conditions. To demonstrate the binding of BCNU...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3635115/ https://ncbi.nlm.nih.gov/pubmed/18633619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-008-0792-9 |
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