Effect of cycloheximide on development of methotrexate resistance of Chinese hamster ovary cells treated with inhibitors of DNA synthesis.

We examined the effects of 18 h of incubation of Chinese hamster ovary (CHO K1) cells with cycloheximide, hydroxyurea, and aphidicolin. Treatment of cells with cycloheximide alone at a concentration adequate to inhibit DNA synthesis to less than 10% of control was significantly less cytotoxic and cl...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Sherwood, S W, Schumacher, R I, Schimke, R T
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1988
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363501/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3405220/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.7.2822-2827.1988
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