Risk of Generalized Vitiligo is Associated with the Common 55R-94A-247H Variant Haplotype of GZMB (Encoding Granzyme B)

Generalized vitiligo (GV) is characterized by autoimmune destruction of melanocytes by skin-homing cytotoxic T-cells (CTLs) that target melanocyte autoantigens. Two recent genomewide association studies (GWAS) of GV in European-derived whites (EUR) have demonstrated genetic association with GZMB, en...

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Hauptverfasser: Ferrara, Tracey M., Jin, Ying, Gowan, Katherine, Fain, Pamela R., Spritz, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634907/
https://ncbi.nlm.nih.gov/pubmed/23321921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2013.5
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