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Glycosylation on Hemagglutinin Affects the Virulence and Pathogenicity of Pandemic H1N1/2009 Influenza A Virus in Mice

The two glycosylation sites (Asn142 and Asn177) were observed in the HA of most human seasonal influenza A/H1N1 viruses, while none in pandemic H1N1/2009 influenza A (pH1N1) viruses. We investigated the effect of the two glycosylation sites on viral virulence and pathogenicity in mice using recombin...

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Detalhes bibliográficos
Main Authors: Zhang, Yan, Zhu, Jiping, Li, Yongtao, Bradley, Konrad C., Cao, Jiyue, Chen, Huanchun, Jin, Meilin, Zhou, Hongbo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634815/
https://ncbi.nlm.nih.gov/pubmed/23637827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061397
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