Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells.

Mammalian ribonucleotide reductase is regulated by the binding of dATP and other nucleotide effectors to allosteric sites on subunit M1. Using mRNA from a mutant mouse T-lymphoma (S49) cell line, we have isolated a cDNA which encodes an altered, dATP feedback-resistant subunit M1. The mutant cDNA co...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Caras, I W, Martin, D W
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1988
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363480/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3043191/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.7.2698-2704.1988
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