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Molecular cloning of the cDNA for a mutant mouse ribonucleotide reductase M1 that produces a dominant mutator phenotype in mammalian cells.

Mammalian ribonucleotide reductase is regulated by the binding of dATP and other nucleotide effectors to allosteric sites on subunit M1. Using mRNA from a mutant mouse T-lymphoma (S49) cell line, we have isolated a cDNA which encodes an altered, dATP feedback-resistant subunit M1. The mutant cDNA co...

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Udgivet i:Mol Cell Biol
Principais autores: Caras, I W, Martin, D W
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363480/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3043191/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.7.2698-2704.1988
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