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piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice
The stable genomic integration and expression of a large transgene is a major hurdle in gene therapy. We show that the modified piggyBac (PB) transposon system can be used to introduce a 207 kb genomic DNA fragment containing the RORγ/γt locus into human cells and mice. PB-mediated transgenesis resu...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Limited
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3634665/ https://ncbi.nlm.nih.gov/pubmed/23519027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010827 |
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