Loss of the E3 ubiquitin ligase LRSAM1 sensitizes peripheral axons to degeneration in a mouse model of Charcot-Marie-Tooth disease

Charcot-Marie-Tooth disease (CMT) is a clinically and genetically heterogeneous condition characterized by peripheral axon degeneration with subsequent motor and sensory deficits. Several CMT gene products function in endosomal sorting and trafficking to the lysosome, suggesting that defects in this...

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Bibliografiska uppgifter
Huvudupphovsmän: Bogdanik, Laurent P., Sleigh, James N., Tian, Cong, Samuels, Mark E., Bedard, Karen, Seburn, Kevin L., Burgess, Robert W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Company of Biologists Limited 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634660/
https://ncbi.nlm.nih.gov/pubmed/23519028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.010942
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