TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease

Bile acids (BAs) play important roles not only in lipid metabolism, but also in signal transduction. TGR5, a transmembrane receptor of BAs, is an immunomodulative factor, but its detailed mechanism remains unclear. Here, we aimed to delineate how BAs operate in immunological responses via the TGR5 p...

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Hlavní autoři: Yoneno, Kazuaki, Hisamatsu, Tadakazu, Shimamura, Katsuyoshi, Kamada, Nobuhiko, Ichikawa, Riko, Kitazume, Mina T, Mori, Maiko, Uo, Michihide, Namikawa, Yuka, Matsuoka, Katsuyoshi, Sato, Toshiro, Koganei, Kazutaka, Sugita, Akira, Kanai, Takanori, Hibi, Toshifumi
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2013
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3634536/
https://ncbi.nlm.nih.gov/pubmed/23566200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12045
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