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High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription
We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H(2)O(2)) but not in normal hematopoietic stem/progenitor cells. High AA sign...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3633866/ https://ncbi.nlm.nih.gov/pubmed/23626851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062717 |
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