High Concentrations of L-Ascorbic Acid Specifically Inhibit the Growth of Human Leukemic Cells via Downregulation of HIF-1α Transcription

We examined the antileukemic effects of high concentrations of L-ascorbic acid (high AA) on human leukemic cells. In vitro, high AA markedly induced apoptosis in various leukemic cell lines by generating hydrogen peroxide (H(2)O(2)) but not in normal hematopoietic stem/progenitor cells. High AA sign...

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Detalhes bibliográficos
Main Authors: Kawada, Hiroshi, Kaneko, Mitsuyo, Sawanobori, Masakazu, Uno, Tomoko, Matsuzawa, Hideyuki, Nakamura, Yoshihiko, Matsushita, Hiromichi, Ando, Kiyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633866/
https://ncbi.nlm.nih.gov/pubmed/23626851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062717
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