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Anthrax Lethal Toxin Downregulates Claudin-5 Expression in Human Endothelial Tight Junctions

Vascular leakage pathologies such as pleural effusion and hemorrhage are hallmarks of anthrax pathogenesis. We previously reported that anthrax lethal toxin (LT), the major virulence factor of anthrax, reduces barrier function in cultured primary human microvascular endothelial cells. Here, we show...

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Detalhes bibliográficos
Main Authors: D’Agnillo, Felice, Williams, Matthew C., Moayeri, Mahtab, Warfel, Jason M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633853/
https://ncbi.nlm.nih.gov/pubmed/23626836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062576
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