Glutamine deficiency in the prefrontal cortex increases depressive-like behaviours in male mice

BACKGROUND: The brain levels of glutamate (Glu) and glutamine (Gln) are partially regulated through the Glu–Gln cycle. Astrocytes play a role in regulating the Glu–Gln cycle, and loss of astrocytes has been associated with depressive disorders. We hypothesized that levels of Glu and Gln would be aff...

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Detalhes bibliográficos
Main Authors: Lee, Younghyurk, Son, Hyeonwi, Kim, Gyeongwha, Kim, Sujeong, Lee, Dong Hoon, Roh, Gu Seob, Kang, Sang Soo, Cho, Gyeong Jae, Choi, Wan Sung, Kim, Hyun Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Canadian Medical Association 2013
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633711/
https://ncbi.nlm.nih.gov/pubmed/23031251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.120024
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