A strategy to determine HLA class II restriction broadly covering the DR, DP and DQ allelic variants most commonly expressed in the general population

Classic ways to determine MHC restriction involve inhibition with locus specific antibodies and antigen presentation assays with panels of cell lines matched or mismatched at the various loci of interest. However, these determinations are often complicated by T-cell epitope degeneracy and promiscuit...

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Detalhes bibliográficos
Main Authors: McKinney, Denise M., Southwood, Scott, Hinz, Denise, Oseroff, Carla, Lindestam Arlehamn, Cecilia S., Schulten, Veronique, Taplitz, Randy, Broide, David, Hanekom, Willem A., Scriba, Thomas J., Wood, Robert, Alam, Rafeul, Peters, Bjoern, Sidney, John, Sette, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633633/
https://ncbi.nlm.nih.gov/pubmed/23392739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-013-0684-y
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