The mineralocorticoid receptor agonist, fludrocortisone, differentially inhibits pituitary-adrenal activity in humans with psychotic major depression

INTRODUCTION: Hypothalamic-pituitary-adrenal (HPA) axis dysregulation has been linked with major depression, particularly psychotic major depression (PMD), with mineralocorticoid receptors (MRs) playing a role in HPA-axis regulation and the pathophysiology of depression. Herein we hypothesize that t...

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Bibliographic Details
Main Authors: Lembke, Anna, Gomez, Rowena, Tenakoon, Lakshika, Keller, Jennifer, Cohen, Gregory, Williams, Gordon H., Kraemer, Fredric B., Schatzberg, Alan F.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633490/
https://ncbi.nlm.nih.gov/pubmed/22727477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.psyneuen.2012.05.006
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