The PPAR-α activator fenofibrate fails to provide myocardial protection in ischemia and reperfusion in pigs

Rodent studies suggest that peroxisome proliferator-activated receptor-α (PPAR-α) activation reduces myocardial ischemia-reperfusion (I/R) injury and infarct size; however, effects of PPAR-α activation in large animal models of myocardial I/R are unknown. We determined whether chronic treatment with...

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Detalhes bibliográficos
Main Authors: Xu, Ya, Lu, Li, Greyson, Clifford, Rizeq, Mona, Nunley, Karin, Wyatt, Beata, Bristow, Michael R., Long, Carlin S., Schwartz, Gregory G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633446/
https://ncbi.nlm.nih.gov/pubmed/16339839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00631.2005
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