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ALOX5 Polymorphism Associates with Increased Leukotriene Production and Reduced Lung Function and Asthma Control in Children with Poorly Controlled Asthma

BACKGROUND: Identification of risk factors for reduced asthma control could improve the understanding and treatment of asthma. A promoter polymorphism in the 5-lipoxygenase gene affects gene expression and response to asthma therapy but its impact on disease control remains unclear. OBJECTIVE: We so...

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Autori principali: Mougey, Edward, Lang, Jason E., Allayee, Hooman, Teague, W. Gerald, Dozor, Allen J., Wise, Robert A., Lima, John J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633142/
https://ncbi.nlm.nih.gov/pubmed/23600541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.12076
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