Pathogenesis of Lethal Cardiac Arrhythmias in Mecp2 Mutant Mice: Implication for Therapy in Rett Syndrome

Rett Syndrome is a neurodevelopmental disorder typically caused by mutations in Methyl-CpG-Binding Protein 2 (MECP2) in which 26% of deaths are sudden and of unknown cause. To explore the hypothesis that these deaths may be due to cardiac dysfunction, we characterized the electrocardiograms (ECGs) i...

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Main Authors: McCauley, Mark D., Wang, Tiannan, Mike, Elise, Herrera, Jose, Beavers, David L., Huang, Teng-Wei, Ward, Christopher S., Skinner, Steven, Percy, Alan K., Glaze, Daniel G., Wehrens, Xander H. T., Neul, Jeffrey L.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633081/
https://ncbi.nlm.nih.gov/pubmed/22174313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3002982
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