Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na(+)-channel-blocking antiepileptic drugs

One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is...

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Bibliographische Detailangaben
Veröffentlicht in:Dis Model Mech
Hauptverfasser: Herrera, José A., Ward, Christopher S., Pitcher, Meagan R., Percy, Alan K., Skinner, Steven, Kaufmann, Walter E., Glaze, Daniel G., Wehrens, Xander H. T., Neul, Jeffrey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Company of Biologists Limited 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381335/
https://ncbi.nlm.nih.gov/pubmed/25713300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.020131
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