Structure-Based Discovery of the Novel Antiviral Properties of Naproxen against the Nucleoprotein of Influenza A Virus

The nucleoprotein (NP) binds the viral RNA genome and associates with the polymerase in a ribonucleoprotein complex (RNP) required for transcription and replication of influenza A virus. NP has no cellular counterpart, and the NP sequence is highly conserved, which led to considering NP a hot target...

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Autores principales: Lejal, Nathalie, Tarus, Bogdan, Bouguyon, Edwige, Chenavas, Sylvie, Bertho, Nicolas, Delmas, Bernard, Ruigrok, Rob W. H., Di Primo, Carmelo, Slama-Schwok, Anny
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2013
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632891/
https://ncbi.nlm.nih.gov/pubmed/23459490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02335-12
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