SIMPL Enhancement of Tumor Necrosis Factor-α Dependent p65-MED1 Complex Formation Is Required for Mammalian Hematopoietic Stem and Progenitor Cell Function

Significant insight into the signaling pathways leading to activation of the Rel transcription factor family, collectively termed NF-κB, has been gained. Less well understood is how subsets of NF-κB-dependent genes are regulated in a signal specific manner. The SIMPL protein (signaling molecule that...

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Détails bibliographiques
Auteurs principaux: Zhao, Weina, Breese, Erin, Bowers, Allison, Hoggatt, Jonathan, Pelus, Louis M., Broxmeyer, Hal E., Goebl, Mark, Harrington, Maureen A.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632537/
https://ncbi.nlm.nih.gov/pubmed/23630580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061123
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