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Improved Vancomycin Dosing in Children Using Area-Under-the-Curve Exposure
BACKGROUND: Our objectives were to: (1) determine the pharmacokinetic [PK] indices of vancomycin in pediatric patients; and (2) compare attainment of two target exposures: AUC/MIC ≥ 400 and trough concentration ≥ 15 mcg/mL. METHODS: The population-based PK modeling was performed using NONMEM 7.2 for...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632448/ https://ncbi.nlm.nih.gov/pubmed/23340565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/INF.0b013e318286378e |
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