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Novel Hypoglycemic Dihydropyridones Serendipitously Discovered from O-versus C-Alkylation in The Synthesis of VMAT2 Antagonists
Vesicular monoamine transporter type 2 (VMAT2) is a newly emerging target for both diagnostic and therapeutic applications in diabetes mellitus. In pursuit of novel VMAT2 antagonists, we identified a potent hypoglycemic agent with a novel dihydropyridone scaffold. Several analogs were designed and s...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632391/ https://ncbi.nlm.nih.gov/pubmed/18752945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.07.129 |
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