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pK(a) Determination of Histidine Residues in α-Conotoxin MII Peptides by (1)H NMR and Constant pH Molecular Dynamics Simulation
α-Conotoxin MII (α-CTxMII) is a potent and selective peptide antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Studies have shown that His9 and His12 are significant determinants of toxin binding affinity for nAChR, while Glu11 may dictate differential toxin affinity between nAChR i...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632324/ https://ncbi.nlm.nih.gov/pubmed/23336579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp3117227 |
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