pK(a) Determination of Histidine Residues in α-Conotoxin MII Peptides by (1)H NMR and Constant pH Molecular Dynamics Simulation

α-Conotoxin MII (α-CTxMII) is a potent and selective peptide antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Studies have shown that His9 and His12 are significant determinants of toxin binding affinity for nAChR, while Glu11 may dictate differential toxin affinity between nAChR i...

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Bibliografiska uppgifter
Huvudupphovsmän: McDougal, Owen M., Granum, David M., Swartz, Mark, Rohleder, Conrad, Maupin, C. Mark
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632324/
https://ncbi.nlm.nih.gov/pubmed/23336579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp3117227
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