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TRANSCRIPTIONAL UPREGULATION OF α(2)δ-1 ELEVATES ARTERIAL SMOOTH MUSCLE CELL CA(V)1.2 CHANNEL SURFACE EXPRESSION AND CEREBROVASCULAR CONSTRICTION IN GENETIC HYPERTENSION
A hallmark of hypertension is an increase in arterial myocyte voltage-dependent Ca(2+) (Ca(V)1.2) currents that induces pathological vasoconstriction. Ca(V)1.2 channels are heteromeric complexes comprising a pore forming Ca(V)1.2α(1) with auxiliary α(2)δ and β subunits. Molecular mechanisms that ele...
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| Asıl Yazarlar: | , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3632309/ https://ncbi.nlm.nih.gov/pubmed/22949532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.199661 |
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