TRANSCRIPTIONAL UPREGULATION OF α(2)δ-1 ELEVATES ARTERIAL SMOOTH MUSCLE CELL CA(V)1.2 CHANNEL SURFACE EXPRESSION AND CEREBROVASCULAR CONSTRICTION IN GENETIC HYPERTENSION

A hallmark of hypertension is an increase in arterial myocyte voltage-dependent Ca(2+) (Ca(V)1.2) currents that induces pathological vasoconstriction. Ca(V)1.2 channels are heteromeric complexes comprising a pore forming Ca(V)1.2α(1) with auxiliary α(2)δ and β subunits. Molecular mechanisms that ele...

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Main Authors: Bannister, John P., Bulley, Simon, Narayanan, Damodaran, Thomas-Gatewood, Candice, Luzny, Patrik, Pachuau, Judith, Jaggar, Jonathan H.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632309/
https://ncbi.nlm.nih.gov/pubmed/22949532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.112.199661
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