Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes of quinolone resistance are mutations of a specific serine or acidic residue in the A subunit of gyrase or topoisomerase IV. These amino acid...

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Bibliographic Details
Main Authors: Aldred, Katie J., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Format: Artigo
Language:Inglês
Published: Oxford University Press 2013
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632122/
https://ncbi.nlm.nih.gov/pubmed/23460203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt124
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