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Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Although quinolones are the most commonly prescribed antibacterials, their use is threatened by an increasing prevalence of resistance. The most common causes of quinolone resistance are mutations of a specific serine or acidic residue in the A subunit of gyrase or topoisomerase IV. These amino acid...

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Autors principals: Aldred, Katie J., McPherson, Sylvia A., Turnbough, Charles L., Kerns, Robert J., Osheroff, Neil
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632122/
https://ncbi.nlm.nih.gov/pubmed/23460203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt124
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