Inhibition of Telomerase Activity by Oleanane Triterpenoid CDDO-Me in Pancreatic Cancer Cells is ROS-Dependent

Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate (CDDO-Me) is a synthetic derivative of oleanolic acid, a triterpene, with apoptosis-inducing activity in a wide range of cancer cells. Induction of apoptosis by CDDO-Me is associated with the generation of reactive oxygen species (ROS) and inhibit...

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Bibliografiske detaljer
Main Authors: Deeb, Dorrah, Gao, Xiaohua, Liu, Yongbo, Varma, Nadimpalli R. S., Arbab, Ali S., Gautam, Subhash C.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3632053/
https://ncbi.nlm.nih.gov/pubmed/23486104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules18033250
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