Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

The lck proto-oncogene encodes a lymphocyte-specific member of the src family of protein tyrosine kinases. Here we demonstrate that pp56lck is phosphorylated in vivo at a carboxy-terminal tyrosine residue (Tyr-505) analogous to Tyr-527 of pp60c-src. Substitution of phenylalanine for tyrosine at this...

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Publicado en:	Mol Cell Biol
Autores principales:	Marth, J D, Cooper, J A, King, C S, Ziegler, S F, Tinker, D A, Overell, R W, Krebs, E G, Perlmutter, R M
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis 1988
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363178/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3352600/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.2.540-550.1988
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