Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

The lck proto-oncogene encodes a lymphocyte-specific member of the src family of protein tyrosine kinases. Here we demonstrate that pp56lck is phosphorylated in vivo at a carboxy-terminal tyrosine residue (Tyr-505) analogous to Tyr-527 of pp60c-src. Substitution of phenylalanine for tyrosine at this...

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Bibliographic Details
Main Authors: Marth, J D, Cooper, J A, King, C S, Ziegler, S F, Tinker, D A, Overell, R W, Krebs, E G, Perlmutter, R M
Format: Artigo
Language:Inglês
Published: 1988
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC363178/
https://ncbi.nlm.nih.gov/pubmed/3352600
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