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Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
Most Forkhead box P3(+) (Foxp3(+)) CD4 regulatory T cell (Treg) precursors are newly formed thymocytes that acquire Foxp3 expression on antigen encounter in the thymus. Differentiation of Treg, however, can also occur in the periphery. What limits this second layer of self- and nonself-reactive Treg...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3631617/ https://ncbi.nlm.nih.gov/pubmed/23576744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1221955110 |
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