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Herpes simplex virus-mediated human hypoxanthine-guanine phosphoribosyltransferase gene transfer into neuronal cells.

The virtually complete deficiency of the purine salvage enzyme hypoxanthine-guanine phosphoribosyltransferase (HPRT) results in a devastating neurological disease, Lesch-Nyhan syndrome. Transfer of the HPRT gene into fibroblasts and lymphoblasts in vitro and into hematopoietic cells in vivo has been...

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Udgivet i:Mol Cell Biol
Principais autores: Palella, T D, Silverman, L J, Schroll, C T, Homa, F L, Levine, M, Kelley, W N
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC363149/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2827006/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.1.457-460.1988
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